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The study, led by Amir Toor from Virginia Commonwealth University Massey Cancer Center's Bone Marrow Transplant Program, retrospectively compared the outcomes of 50 patients who received rabbit anti-thymocyte globulin (ATG) before receiving a transplant of stem cells from an unrelated donor to the outcomes of 48 patients who received a transplant of stem cells from a related donor.
Scientists injected rabbits' anti-thymocyte globulin (ATG) into one group of patients who were going to receive stem cells from an unrelated donor whereas the other group received the stem cells from a related donor.
In total, 9 patients that could not be treated with equine anti-thymocyte globulin (hATG) following diagnosis received high-dose methylprednisolone treatment.
But instead of receiving rabbit anti-thymocyte globulin during surgery and at intervals the following days, patients received a one-time dose just hours before transplantation.
A steroid-free treatment of rabbit anti-thymocyte globulin (rabbit ATG, Thymoglobulin(R)) may decrease the incidence of organ rejection, diabetes and hepatitis C in liver transplant recipients, according to a study conducted by James D.
The first group included 32 patients who received a 2-week course of induction therapy with rabbit anti-thymocyte globulin (rabbit ATG, Thymoglobulin(R)) and a short course of steroids for only six days.
Initial studies were performed in two to three antigen HLA-mismatched transplants using anti-thymocyte globulin as a method of T-cell depletion.
Previously, 13 patients were similarly treated with an earlier AlloMune(TM) Cancer system prototype using anti-thymocyte globulin (ATGAMR) and bone marrow in patients with one or two HLA antigen mismatches, yet 77% of these patients demonstrated GvHD following treatment.