These authors found no association between protein S deficiency and CD4+ lymphocyte count, cy (CMV) status, HIV p24 antigen, von Willebrand factor antigen, IgG anti-cardiolipin antibodies, or serum beta-2-microglobulin levels.
Other than an expected slightly below-normal protein C level, all other laboratory studies, including protein S, factor V Leiden, homocysteine, prothrombin G, fibrinogen, antiphospholipid antibody, lupus anticoagulant and anti-cardiolipin antibody, were all within normal limits.
For example: * Negative control indices and positive controls did not meet specifications for the product Syphilis Trepchek; * Increase in false positives for Syphilis Trepchek; undissolved particles in the diluent caused the product Aptus probe to aspirate inconsistent volume of diluent; * High recoveries for the negative control and low calibrator recovery for the product anti-Cardiolipin IgG; and * High sample recoveries for the product Apo-Tek Lp(a).
By testing serum samples from 113 SLE patients for a series of risk factors, it was concluded the measurement of AtherOx antibody was significantly better than conventional anti-cardiolipin testing in identifying patients with vascular complications, and illustrates a pivotal role of b2GPI in vascular injury and thrombosis.
