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What does IAP stand for?

IAP stands for Anti-Apoptotic Protein

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We have 401 other meanings of IAP in our Acronym Attic

Samples in periodicals archive:

The results of these studies also suggest the inhibition of NF-kB activation, the suppression of anti-apoptotic proteins, such as IAP, c-FLIP, Akt kinase, and the initiation of extrinsic pathway of apoptosis by induction of TRAIL and Fas receptor stimulation in cancer cells.
The Bcl-2 family of proteins contains both pro-apoptotic members (BAX, BAK) and anti-apoptotic proteins (Bcl-2 Bcl-xl, Bcl-w) and plays a key role in the decision to undergo mitochondrial (intrinsic) apoptosis [47].
In addition to AEG33773, Aegera has three programs in clinical development for oncology indications: - AEG35156 targets the key anti-apoptotic protein XIAP, and is currently in multiple Phase II human clinical trials for the treatment of solid tumors and leukemia; - AEG41174 is a novel, non-ATP competitive, small molecule tyrosine kinase inhibitor targeting therapeutically significant kinases including JAK2 and Bcr-Abl, and is currently in Phase 1 clinical studies; - AEG40826 (HGS1029) is a small molecule IAP inhibitor that has shown promising preclinical activity alone and in combination with other anti-neoplastic agents across a broad range of cancers.