What does IAP stand for?

Through increased expression of both pro-oncogenic and anti-apoptotic proteins, epithelial cells in colonic tissues underwent both enhanced proliferation and survival.

Inhibition of these pathways leads to prevention of phosphorylation of key anti-apoptotic proteins such as XIAP and FLIPs.

BRE is an anti-apoptotic protein in vivo and over-expressed in human hepatocellular carcinoma.

In addition to HGS1029 (AEG40826), Aegera has the following programs in clinical development: AEG35156 is a DNA antisense oligonucleotide that targets the key anti-apoptotic protein XIAP, and is currently in multiple Phase 2 human clinical trials for the treatment of solid tumors and hematological malignancies; and AEG33773 is a first-in-class oral small molecule HSP90 modulator, which is in Phase 2a development for the treatment of painful diabetic neuropathy in North American and Europe.

In contrast, PRAF1 may inhibit the herpes virus life cycle by sequestering BHRF1, an anti-apoptotic protein, to the Golgi complex.

Further, anti-apoptotic proteins such as Bcl-2 and baculovirus protein p35 are well known for their antioxidant properties (38,39).

This finding suggests that the anti-apoptotic protein Bcl-xl may play an important role in the mechanism of metastases.

; Room 505-507): "Degradation of the anti-apoptotic protein MCL-1 correlates with mitotic cell death in response to the novel KSP inhibitor ARRY-520" investigates the molecular basis for sensitivity to ARRY-520 in hematological tumors.