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Inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF-a) play a major role in the pathophysiology of anemia in cancer, also known as anemia of chronic disease (ACD).
Different types of anemia, including iron deficiency anemia (IDA), anemia of chronic disease (ACD), the combination of IDA and ACD (COMBI) anemia, megaloblastic anemia, and hemolytic anemia, have been seen in patients with RA.
16) Iron deficiency anemia and anemia of chronic disease are the main types of anemia in IBD.
Anemia in the elderly can be attributed to a variety of causes including anemia of chronic disease (anemia of inflammation), nutritional deficiencies, renal disease, acute or chronic blood loss, hemolytic disorders, and others.
Anemia of chronic disease and hyperbilirubinemia can decrease the specificity of an iron deficiency diagnosis based on hematofluorometry-determined increases in the ratio of ZnPPIX to heme.
Laboratory data was significant for an anemia of chronic disease.
Laboratory tests demonstrated anemia of chronic disease diagnosed by a hematocrit of 25% associated with a low reticulocyte production index, high serum ferritin, and an elevated erythrocyte sedimentation rate (91 mm/hr), with polyclonal hypergammaglobulinemia and hypoalbuminemia on serum protein electrophoresis.
Anemia of chronic disease (ACD), also known as anemia of inflammation, is a hypoproliferative anemia that develops in response to systemic illness or inflammation such as infection, cancer, and autoimmune conditions.