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Combination therapy using MCP allows lower levels of Doxorubicin to be used with greater effect on inducing rapid cell death in the hard-to-treat androgen-independent prostate cancer cells, and halting the viability of the androgen-dependent prostate cancer cells.
Although very efficient at reducing cancer growth and volume, this treatment eventually selects for cells that are no longer responsive to such therapy, resulting in a recurring lethal cancer termed androgen-independent prostate cancer (AIPC)  (3).
Patrick Ling and colleagues demonstrated that gamma-tocotrienol downregulates the expression of prostate cancer stem cell markers in androgen-independent prostate cancer cell lines.
Our results suggest a need for clinical trials to determine whether a combination of Lipitor and Celebrex will inhibit or prevent the transition of androgen-dependent prostate cancer, which is the easily treatable form of the tumor, to the more aggressive androgen-independent prostate cancer," Dr.
Novacea is currently conducting a large international Phase 3 trial (ASCENT-2) evaluating Asentar in 900 patients with androgen-independent prostate cancer (AIPC).
2002) and show characteristics of advanced, androgen-independent prostate cancer (Benbrahim-Tallaa et al.
This study will focus on patients with androgen-independent prostate cancer, relapsing or progressing after a previous line of docetaxel-based chemotherapy.
to initiate the CRITICAL (CRyotherapy and IntraTumoral Immunotherapy with immature dendritic Cells (AutoLogous)) trial, a clinical trial examining the potential of a novel combination of cryoablation and intra-tumoral injection of "virgin" dendritic cells (VDC2008) to treat men with metastatic androgen-independent prostate cancer.