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The condition required in their package 2 As recommended by the worldwide organization of bone marrow donors to mobilize cells from healthy donors for allogeneic bone marrow transplantation.
In SCD patients with severe clinical symptoms, allogeneic bone marrow transplantation can be used to replace the blood cell producing capacity, potentially curing them of the disease.
Toubert ME, Socie G, Gluckman E, Aractingi S, Esperou H, Devergie A, Ribaud P, Parquet N, Schlageter MH, Beressi JP, Rain JD, Vexiau P Short- and long-term follow-up of thyroid dysfunction after allogeneic bone marrow transplantation without the use of preparative total body irradiation.
Kiadis Pharma recently announced that its lead product ATIR has been granted orphan drug designation by the FDA as a therapy for immune reconstitution and prevention of Graft versus Host Disease (GvHD) following allogeneic bone marrow transplantation.
The assessment of chimerism, the ratio of donor to recipient cells, is critical for monitoring the engraftment of donor cells and determining the recurrence of the original disease after allogeneic bone marrow transplantation (BMT).
ALD is currently treated with allogeneic bone marrow transplantation when there is an appropriate donor.
The Company believes that this would expand the use of allogeneic bone marrow transplantation to all those in need of the procedure but who currently cannot find a donor, with the potential to expand the total number of unrelated donor transplants performed by three- to four-fold.
In addition, the FDA has granted ATIR(TM) an Orphan Drug Designation as a cell based therapy for the reduction of Transplant Related Mortality caused by Graft versus Host Disease (GvHD) and/or infections following allogeneic bone marrow transplantation.