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If renin is rendered "unsuppressed" by drugs such as diuretics, there is a risk that it could lead to stimulation, via angiotensin II, of aldosterone production by the contralateral, otherwise suppressed adrenal gland in patients with an aldosterone-producing adenoma.
The two major subtypes of primary hyperaldosteronism are bilateral idiopathic hyperaldosteronism and aldosterone-producing adenoma (APA) (1,2).
It also can determine whether the condition, known as Conn's syndrome, is a result of an aldosterone-producing adenoma or bilateral adrenal hyperplasia, a distinction that is important because only with an adenoma is surgery the appropriate treatment.
The drug appeared to be safe and effective in a 17-year follow-up of medical therapy in patients who had refused surgery for an aldosterone-producing adenoma.
1) years; age range, 26-72 years]: 9 patients had aldosterone-producing adenomas (APRs), 18 had idiopathic hyperaldosteronism (IHA), and 1 patient had glucocorticoid-suppressible hyperaldosteronism.