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Samples in periodicals archive:
lucidum showed the strongest aldose reductase inhibition among 17 edible and medicinal mushrooms (Fatmawati et al.
The discovery that aldose reductase regulates mucus production and goblet cell metaplasia makes inhibition of this enzyme an attractive therapeutic option to reduce mucus-related airway obstructive diseases - and for the first time gives us a real chance to alter the course of the underlying disease in asthma and COPD," said UTMB Health biochemistry and molecular biology professor Satish Srivastava, senior author of the paper.
Galactitol is produced from galactose intracellularly by aldose reductase with variable leakage into the plasma.
The papers represent the latest research in aldehyde dehydrogenases (including such topics as unexpected encounters in simulations f the ALDH mechanism and detoxification of chloroacetaldehyde by human class-9 aldehyde dehydrogenase), alcohol dehydrogenases (including functional roles of alcohol dehydrogenases in human ethanol metabolism and the diversity of beta-hydroxyacid dehydrogenases in plants), carbonyl reductases (including life without aldose reductase, lead optimization in the design of aldose reductase inhibitors and characterizations of a number of test animal organs).
The company has confirmed that chalcones have insulin-like activity and aldose reductase inhibitory activity so that they help prevent and cure diabetes.
The up-regulated proteins were mostly heat-shock proteins (HSPs) and anti-oxidative stress proteins, including HSP70, aldose reductase, heme oxygenase-1, HSP27, ferritin light chain, and alphaB-crystallin.
The first step involves a reduction into galactitol by using NADH-dependent aldose reductase from yeast and continuously regenerates the NADH.
But on a more immediate and practical level, diabetics still have unavoidably large changes in blood glucose, and drugs to reduce levels of sorbitol by inhibiting the aldose reductase enzyme are viewed as a simpler, more effective way to achieve the same result.