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About Aldea Pharmaceuticals Aldea Pharmaceuticals is focused on developing small molecule modulators of the aldehyde dehydrogenase enzyme superfamily.
In the first step, aldehyde dehydrogenase (ALDH), cytochrome P450 (CYP2E1), alcohol dehydrogenase (ADH), and catalase are involved in metabolic elimination of alcohol.
The research showed that certain pesticides that inhibit an enzyme called aldehyde dehydrogenase (ALDH) are related to an increased risk of Parkinson's disease.
For example, they led to strong evidence that genes that encode the two main enzymes involved in alcohol metabolism--alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)--affect risk, which will be discussed in the next section.
A year ago, Ziouzenkova's lab identified the one of these enzymes that relates to fat accumulation: Aldehyde Dehydrogenase 1, or Aldh1a1.
Palifosfamide (Zymafos(R) or ZIO-201) is a novel DNA cross-linker that in preclinical study has been shown to bypass resistance mediated by aldehyde dehydrogenase (ALDH), in addition to conferring a favorable toxicity profile compared to other in-class agents.
Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme in ethanol metabolism.
Aof people from Asia lack the enzyme aldehyde dehydrogenase.