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Adenovirus type 5 (Adeno-X[TM] AcGFP1 Marker Virus) encoding the green fluorescent protein (GFP) under the immediate early promoter of human cytomegalovirus was obtained from Clontech Laboratories (Mountain View, Ca, USA).
Although the difference in infection rates between the vaccine and placebo groups across the entire study population was only "marginally statistically significant," in the subgroup of participants with high levels of adenovirus type 5 (Ad5) immunity--defined as antibody levels greater than 200 U--the statistical significance between the two groups was more robust.
In this system, only the cis-acting elements (required for viral DNA replication and packaging) are derived from adenovirus type 5.
The randomized controlled study was conducted in 40 eyes of 20 rabbits experimentally inoculated with human adenovirus type 5.
The functions of E4 ORF 6/7 peptides of Ad7 are unknown, but the corresponding protein of adenovirus type 5 has the ability to induce the binding of cellular transcription factor E2F to the viral E2a promoter region (26).
Adenovirus type 5 is one of many upper-respiratory viruses responsible for the common cold.
Oncolys BioPharma -Telomelysin([R]), an adenovirus type 5 vector carrying the human telomerase reverse transcriptase (hTERT) gene.
The prime-boost regimen uses Merck's replication-defective adenovirus type 5 vector (Ad5) vaccine candidate first, followed by the canarypox virus vector (ALVAC) vaccine candidate from Aventis Pasteur, the vaccines business of Aventis.