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Data from 23 animals were accumulated, and the efficacy of LTCI therapy was based upon absolute lymphocyte counts and improvement in clinical symptoms.
They also maintained low absolute lymphocyte counts (ALC) and minimal immune system function, leading the researchers to believe that ERT may weaken the therapy's effect by diluting the number of gene-corrected lymphocytes.
Background: For cancer patients, the absolute lymphocyte count in peripheral blood has well-substantiated prognostic potential for recurrence free survival and survival following chemotherapy.
No significant differences were found between ZAP-70 positivity and other parameters, including the absolute lymphocyte count at presentation, patient age at presentation, or the presence of an unusual CLL immunophenotype (including expression of FMC7, CD22, or CD79b).
63 Absolute CD4 cell count 6 mo after 368 disease, /[micro]L Absolute lymphocyte count 6 mo after 2,098 disease, /[micro]L Demographic/clinical characteristic Patient 2 Patient 3 Sex M M Age, y 18 20 Other coexisting conditions None None Date of SARS onset Apr 7, 2003 Apr 4, 2003 Date of TB diagnosis Jan 24, 2003 Mar 5, 2003 Date of hospitalization or transfer to Apr 7, 2003 Apr 5, 2003 SARS ward Leukocyte count at admission, /[micro]L 6,800 2,500 Total steroid dose used, mg 2,600 3,600 Intensive care unit admission No No CD4/CD8 cell ratio 6 mo after disease 1.
The study reported that sixteen out of nineteen evaluable patients achieved stable disease or better after treatment with REVLIMID, and experienced a median decrease of 61 percent in absolute lymphocyte count (ALC), a measure of tumor burden.
1) This, of course, led to significant concerns when following patients with HIV infections since the CD4+ counts require an accurate absolute lymphocyte count and are critical for the diagnostic and therapeutic decisions in these patients.
In four patients (patients 1, 2, 3, and 7), the absolute lymphocyte count became lower spontaneously during the period of observation (no treatment).