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What does TGN stand for?

TGN stands for 6-Thioguanine Nucleotides

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Samples in periodicals archive:

Azathioprine is converted to 6-mercaptopurine, which can be metabolized by xanthine oxidase to oxidized metabolites, by hypoxanthine-guanine phosphoribosyl transferase (HPRT) to 6-thioguanine nucleotides, or by thiopurine methyl transferase (TPMT) to 6-methylmercaptopurine (Fig.
The immunosuppressive properties are related to intracellular conversion into thiopurine nucleotides via hypoxanthine guanine phosphoribosyl transferase, leading to 6-thioguanine nucleotides (6-TGNs),[1] and methylation of 6-thioinosine monophosphate via thiopurine methyltransferase, leading to methyl 6-methylmercaptopurine (Me6-MP) nucleotides (2).
3) This anabolic route leading to 6-thioguanine nucleotides (6-TGNs) is in competition in red blood cells (RBCs) with methylation of 6-TIMP into methyl 6-TIMP (Me6-TEMP) via thiopurine S-methyltransferase (TPMT), a cytosolic, S-adenosyl methionine-dependent enzyme.